Aged garlic extract plus supplements (AGE-S) showed simultaneous cardioprotection and prevention of osteoporosis by improving bone mineral density, endothelial function and its anti-inflammatory effects.

  • Osteoporosis and atherosclerosis are the two major health care problems that coexist in both the genders.
  • The effects of aged garlic extract plus supplements (AGE-S) on bone mineral density (BMD) levels, inflammatory markers, vascular function and coronary artery calcium (CAC) were investigated the present study.
  • The patients were randomized and were given either placebo or four capsules per day of AGE-S. The AGE-S included AGE (250 mg), vitamin B6 (12.5 mg), B12 (100 μg), folate (300 μg) and L-Arginine (100 mg).

All the patients were evaluated at baseline and after 12 months follow up and were compared with the placebo treated group. The findings observed in AGE-S group compared to placebo group were as follows:

  • Increase in post cuff-deflation temperature-rebound (TR), high density lipoprotein (HDL-C), Lp-a.
  • Decrease in total cholesterol, low density lipoprotein (LDL-C), triglyceride and homocysteine .
  • Lack of increase in coronary artery calcium (CAC)
  • Lack of decrease in bone mineral density (BMD)

Fig: Thoracic bone mineral density measured from non-enhanced coronary artery calcium CT scans. The coronary calcium score (green circle) was measured, and the BMD (red square) was measured in four consecutive thoracic trabecular vertebrae (T-7 to T-10) below the slice level of left main coronary (green arrow). The 10-mm region of interest (ROI) inside trabecular bone was used to measure BMD levels. The calibration phantom (yellow arrow) was used to calibrate the CT scanner to measured density in mg/cm3


Correlations observed:

Decrease of BMD with increase in coronary artery calcium.

Increase of levels of BMD with increase in TR and decrease in homocystein

Maximum beneficial effect of AGE-S was noted with increase in TR, lack of decrease in bone mineral density and coronary artery calcium non-progression.

Ahmadi et al. Aged Garlic Extract with Supplement is Associated with Beneficial Effect on Bone Mineral Density and Predicts Lack of Progression of Atherosclerosis: A Prospective Double Blinded Randomized Trial. International Journal of Cardiovascular Research. 2015, 4:3.

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