Depression is a risk factor for CHD, non adherence to antidepressant medication (SSRIs) further contributes to it. Selective serotonin reuptake inhibitor (SSRI) medication positively influences pathogenesis and biomarkers of CHD in depressed conditions.
- Depression has been noted as a risk factor for coronary heart disease (CHD) and notably patients with CHD are prone to depression.
- The key aspects of CHD, inflammation and metabolic dysregulation were reported to be increased during depression contributing to 1.9 fold increased CHD risk.
- CHD being a cause of mortality, how far the treatment of depressed could tamper this risk?
- It is observed that selective serotonin reuptake inhibitors (SSRIs) treated depressed patients had 2 fold reductions in CHD risk compared to untreated.
- SSRIs positively impacts coagulation, oxidative stress and metabolism processes that are deregulated/ negatively impacted by depression and indicated in CHD risk. These observations were also noted by positive changes in CHD biomarker levels.