Depression is a risk factor for CHD, non adherence to antidepressant medication (SSRIs) further contributes to it. Selective serotonin reuptake inhibitor (SSRI) medication positively influences pathogenesis and biomarkers of CHD in depressed conditions.

  • Depression has been noted as a risk factor for coronary heart disease (CHD) and notably patients with CHD are prone to depression.
  • The key aspects of CHD, inflammation and metabolic dysregulation were reported to be increased during depression contributing to 1.9 fold increased CHD risk.
  • CHD being a cause of mortality, how far the treatment of depressed could tamper this risk?
  • It is observed that selective serotonin reuptake inhibitors (SSRIs) treated depressed patients had 2 fold reductions in CHD risk compared to untreated.
  • SSRIs positively impacts coagulation, oxidative stress and metabolism processes that are deregulated/ negatively impacted by depression and indicated in CHD risk. These observations were also noted by positive changes in CHD biomarker levels.
Citation
Mathews et al. The mechanisms by which antidepressants may reduce coronary heart disease risk. Cardiovascular Disorders. 2015, 15:82.

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