Targeting the ACE2/Apelin signalling and miRNAs could lead to the development of a novel therapeutic approach for patients with hypertension and other vascular diseases related to cardiovascular remodeling.

  • Hypertension is a complex cardiovascular disease. Recent studies have demonstrated that there is a link between the ACE2/Apelin signalling and microRNAs (miRNAs) in the pathogenesis of hypertension.
  • Deregulation of miRNAs expression play role in the development of hypertension. Various miRNAs in vasculature play role in cell proliferation, differentiation, de-differentiation etc process. They have both positive and negative effects in the pathogenesis which provide novel pharmacological implications for the prevention and treatment of hypertension.
  • Inhibition of the ACE/Ang II/AT1R signalling has been regarded as important pharmacological tools to prevent and treat vascular diseases such as hypertension.

Fig above: Crosstalk between the ACE2/Apelin signaling and miRNAs in hypertension. {ACE: angiotensin converting enzyme; ACE2: angiotensin converting enzyme 2; Ang II: angiotensin; AT1R: angiotensin II type 1 receptor; miRNAs: microRNAs; FGF2: fibroblast growth factor 2; FGFR1: fibroblast growth factor receptor 1.}

However this is just a beginning to the understanding of this new pathway, corresponding targets and functional roles of the ACE2/Apelin-related miRNAs still need to be identified and validated.

Chen et al. The ACE2/Apelin Signaling, MicroRNAs, and Hypertension. International Journal of Hypertension. Volume 2015 (2015), Article ID 896861, 6 pages.

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